Table 4.
GWAS loci with CNVs associated with EOC or HGSOC risk (P < .05)
| Cytoband | rsID | GWAS P | LD block start | LD block end |
|---|---|---|---|---|
| NMOC loci | ||||
| 3q28 | rs9869209 | 6.61E-09 | 190508818 | 192626025 |
| 5p15.33 | rs4449583 | 2.76E-21 | 982137 | 2132328 |
| 10p12.31 | rs7084454 | 1.86E-12 | 19427949 | 22483354 |
| 17q21.31a | rs146596949 | 1.26E-51 | 41743558 | 43694719 |
| 17q21.31a | rs575499584 | 4.12E-18 | 44979537 | 47798656 |
| 17q21.32 | rs12946636 | 9.92E-25 | 47798656 | 49440038 |
| 19p13.11 | rs4808075 | 5.76E-26 | 16263605 | 18299052 |
| HGSOC associated loci | ||||
| 4q13.2/4q13.3 | rs4149419 | 2.66E-08 | 67989047 | 70183435 |
| 5p15.33 | rs4449583 | 1.09E-19 | 982137 | 2132328 |
| 9q31.1 | rs2122577 | 2.94E-09 | 103205694 | 104819468 |
| 9p22.1/9p21.3 | rs7851336 | 2.54E-10 | 18661053 | 20463536 |
| 10p12.31 | rs7084454 | 1.48E-09 | 19427949 | 22483354 |
| 13q13.1 | rs11571815 | 4.32E-09 | 31727678 | 33202766 |
| 15q26.1 | rs76119208 | 3.36E-09 | 89932319 | 91621162 |
| 17q12 | rs11657964 | 2.63E-12 | 36141651 | 38653091 |
| 17q21.31 | rs146596949 | 3.11E-56 | 41743558 | 43694719 |
| 17q21.31 | rs575499584 | 1.69E-19 | 44979537 | 47798656 |
| 17q21.32 | rs12946636 | 5.54E-19 | 47798656 | 49440038 |
| 19p13.11 | rs56069439 | 8.41E-38 | 16263605 | 18299052 |
a
BRCA1 locus. CNV = copy number variants; GWAS = genome-wide association analysis; LD = linkage disequilibrium; HGSOC = high-grade serous ovarian cancer; NMOC = all nonmucinous ovarian cancer.