Table 1.
Descriptive information on the TNFRSF1A variants analyzed in the study and their associations with inflammatory markers and disease outcomes.
| Instrumental variables | rs1800693 a | rs767455 b | rs4149570 b | rs4149577 b |
|---|---|---|---|---|
| Frequency of EA c | 0.574 | 0.571 | 0.374 | 0.528 |
| F-statistic | 118.805 | 98.010 | 54.020 | 81.996 |
| Associations with the inflammatory marker, β (SE), p-value | ||||
| C-reactive protein | 0.022 (0.002), 9.56e-27 | 0.020 (0.002), 2.39e-22 | 0.015 (0.002), 5.23e-13 | 0.018 (0.002), 9.60e-19 |
| Associations with the outcome, β (SE), p-value | ||||
| Periodontitis | 0.010 (0.016), 0.530 | 0.013 (0.016), 0.405 | 0.004 (0.016), 0.799 | 0.006 (0.015), 0.685 |
EA, effect allele; NEA, non-effect allele.
a
SNP used in our primary analysis for the Wald ratio estimation.
b
SNPs used in our secondary analysis for causal estimation from the multiplicative fixed-effects model and the principle component analysis method.
c
Based on allele frequency reported by the genome-wide association studies of C-reactive protein. Single nucleotide polymorphisms were labeled with respect to GRCh37 reference coordinates.