Table 2.
Mendelian randomization estimates for the effect of tumor necrosis factor receptor 1 inhibition on periodontitis risk.
| Periodontitis | ||||
|---|---|---|---|---|
| Exposure | OR | 95% CI | P-value | |
| CRP | Wald ratio a | 1.57 | (0.38;6.46) | 0.53 |
| IVW b | 0.57 | (0.12;2.57) | 0.46 | |
| IVW using PCA c | 0.57 | (0.13;2.63) | 0.55 | |
CI, confidence interval; CRP, C-reactive protein; IVW, inverse variance weighted; MPV, mean platelet volume; OR, odds ratio; PCA, principal component analysis.
a
Wald ratio of a single SNP, rs1800693.
b
IVW for correlated single nucleotide polymorphisms (SNPs) utilized Wald ratios of 3 SNPs (rs767455, rs4149570, and rs4149577).
c
IVW using principal components analyses assumed correlated SNPs and are based on Mendelian randomization models of 2 principal components derived from the genetic associations of 3 correlated SNPs (rs767455, rs4149570, and rs4149577).