Table 2. Severity of symptoms at enrolment into WATCH trial (baseline) compared with primary endpoint time (day 7), stratified by AOM resolution at Day 7.
| Symptoms (’a lot’) |
AOM resolution at day 7 (n = 113) |
Persistent AOM at day 7 (n = 75) |
||||
|---|---|---|---|---|---|---|
| Baseline n (%) |
day 7 n (%) |
Relative change from baseline (%) | Baseline n (%) |
day 7 n (%) |
Relative change from baseline (%) | |
| Runny nose | 55 (48.7) | 9 (8.0) | -84 | 29 (38.7) | 10 (13.3) | -66 |
| Coughing | 49 (43.4) | 10 (8.8) | -80 | 29 (38.7) | 13 (17.3) | -55 |
| Irritable/fussy | 45 (39.8) | 5 (4.4) | -89 | 26 (34.7) | 8 (10.7) | -69 |
| Difficulty sleeping | 37 (32.7) | 5 (4.4) | -86 | 21 (28.0) | 4 (5.3) | -81 |
| Crying | 33 (29.2) | 7 (6.2) | -79 | 15 (20.0) | 3 (4.0) | -80 |
| Tugging, rubbing ears | 32 (28.3) | 2 (1.8) | -94 | 12 (16.0) | 7 (9.3) | -42 |
| Ear pain | 28 (24.8) | 0 (0.0) | -100 | 21 (28.0) | 8 (10.7) | -62 |
| Fever | 22 (19.5) | 4 (3.5) | -82 | 7 (9.3) | 4 (5.3) | -43 |
| Eating less | 19 (16.8) | 4 (3.5) | -79 | 18 (24.0) | 2 (2.7) | -89 |
| Less playful | 14 (12.4) | 4 (3.5) | -71 | 6 (8.0) | 1 (1.3) | -83 |
| Vomiting | 3 (2.7) | 1 (0.9) | -67 | 1 (1.3) | 1 (1.3) | 0 |
| Diarrhoea | 2 (1.8) | 1 (0.9) | -50 | 0 (0.0) | 1 (1.3) | N/A |
| Rash | 1 (0.9) | 1 (0.9) | 0 | 1 (1.3) | 2 (2.7) | 100 |
N/A = not applicable