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. 2023 Jan 19;66(3):1909–1927. doi: 10.1021/acs.jmedchem.2c01713

Table 2. Inhibition of Recombinant HDAC1 by the First Library of Azobenzenesa.

  IC50 (μM)
  
compound dark light IC50(dark)/IC50(light)
17 0.42 2.9 0.14
1 0.96 0.052 18
18 1.2 0.20 6
11 >10 0.20 >50
20 >10 0.35 >29
21 >10 3.4 >2.9
a

IC50 values under either dark or illumination (365 or 380 nm) conditions, measured by a fluorescence assay.