Table 2.

Clusters exhibiting group differences in mask-restricted or whole brain analyses of fractional amplitude of low-frequency fluctuations. Models included adjustment for sex and site.

Regiona	Clusterb (x, y, z)c			Size	Peaks	TFCE	Peak p-FWE	Peak p-unc	Analyses; Comparison
R Anterior Insula	+44	+08	−10	42	1	146.73	0.017667	0.000069	MR; HC > Hyper
R Lateral OFC	+40	+32	−14	30	3	125.40	0.035667	0.000191	MR; Hyper > HC
R Anterior Insula	+44	+10	−10	32	1	411.98	0.037000	0.000031	WB; HC > Hyper

Abbreviations: FWE = Family-wise error; HC = Healthy comparison group; Hyper = Hyperphagic major depressive disorder group; MR = Mask-restricted; OFC = Orbitofrontal cortex; R = Right; TFCE = Threshold-free cluster enhancement; unc = uncorrected; WB = Whole brain

^aRegion with the most voxels within the relevant cluster

^bOnly clusters with more than 20 voxels are reported

^cMontreal Neurological Institute (MNI)