Table 3.
Clusters exhibiting group differences in mask-restricted or whole brain analyses of seed-based connectivity (with the right lateral OFC as the seed). Models included adjustment for sex and site.
Regiona | Clusterb (x, y, z)c | Size | Peaks | TFCE | Peak p-FWE | Peak p-unc | Analyses; Comparison | ||
---|---|---|---|---|---|---|---|---|---|
L Anterior Insula | −42 | +14 | +00 | 89 | 1 | 173.71 | 0.045000 | 0.001030 | MR; HC > Hyper |
L Precentral Gyrus | −04 | −28 | +72 | 24 | 3 | 593.07 | 0.047000 | 0.000282 | WB; Hyper > HC |
Abbreviations: FWE = Family-wise error; HC = Healthy comparison group; Hyper = Hyperphagic major depressive disorder group; L = Left; MR = Mask-restricted; OFC = Orbitofrontal cortex; TFCE = Threshold-free cluster enhancement; unc = uncorrected; WB = Whole brain
Region with the most voxels within the relevant cluster
Only clusters with more than 20 voxels are reported
Montreal Neurological Institute (MNI)