Table 3.
Adverse Effects of More Than Mild Severity
| Side Effect | JNJ-67953964 N=45 | Placebo N=44 | ||
|---|---|---|---|---|
| 1N | 2% | 1N | 2% | |
| Headache | 5 | 11.1% | 4 | 9.1% |
| Pruritus | 5 | 11.1% | 1 | 2.3% |
| Anxiety | 3 | 6.7% | 2 | 4.5% |
| Insomnia | 3 | 6.7% | 2 | 4.5% |
| Suicidal ideation | 3 | 6.7% | 2 | 4.5% |
| Diarrhea | 1 | 2.2% | 3 | 6.8% |
| Constipation | 2 | 4.4% | 1 | 2.3% |
| Depression | 3 | 6.7% | 0 | 0.0% |
| Dizziness | 2 | 4.4% | 1 | 2.3% |
| Fatigue | 1 | 2.2% | 2 | 4.5% |
| Rash | 3 | 6.7% | 0 | 0.0% |
| Restlessness | 1 | 2.2% | 2 | 4.5% |
| Vision blurred | 2 | 4.4% | 1 | 2.3% |
| Arthralgia | 1 | 2.2% | 1 | 2.3% |
| Disturbance in attention | 1 | 2.2% | 1 | 2.3% |
| Dry mouth | 1 | 2.2% | 1 | 2.3% |
| Nausea | 0 | 0.0% | 2 | 4.5% |
| Panic attack | 1 | 2.2% | 1 | 2.3% |
| Pollakiuria | 2 | 4.4% | 0 | 0.0% |
| Pyrexia | 0 | 0.0% | 2 | 4.5% |
| Back pain | 0 | 0.0% | 1 | 2.3% |
| Blepharitis | 1 | 2.2% | 0 | 0.0% |
| Chest pain | 1 | 2.2% | 0 | 0.0% |
| Coordination abnormal | 0 | 0.0% | 1 | 2.3% |
| Costochondritis | 1 | 2.2% | 0 | 0.0% |
| Cough | 0 | 0.0% | 1 | 2.3% |
| Dry skin | 0 | 0.0% | 1 | 2.3% |
| Dysuria | 1 | 2.2% | 0 | 0.0% |
| Eye pruritus | 0 | 0.0% | 1 | 2.3% |
| Fall | 0 | 0.0% | 1 | 2.3% |
| Hyperhidrosis | 0 | 0.0% | 1 | 2.3% |
| Hypersomnia | 0 | 0.0% | 1 | 2.3% |
| Irritability | 1 | 2.2% | 0 | 0.0% |
| Libido decreased | 0 | 0.0% | 1 | 2.3% |
| Muscle twitching | 1 | 2.2% | 0 | 0.0% |
| Musculoskeletal chest pain | 0 | 0.0% | 1 | 2.3% |
| Nasopharyngitis | 0 | 0.0% | 1 | 2.3% |
| Night sweats | 0 | 0.0% | 1 | 2.3% |
| Palpitations | 0 | 0.0% | 1 | 2.3% |
| Self-injurious ideation | 1 | 2.2% | 0 | 0.0% |
| Tendon rupture | 1 | 2.2% | 0 | 0.0% |
| Toothache | 0 | 0.0% | 1 | 2.3% |
| Upper respiratory tract infection | 0 | 0.0% | 1 | 2.3% |
| Viral infection | 1 | 2.2% | 0 | 0.0% |
1
N = number of subjects experiencing this event at least once (not total number of events)
2
% = percent that experienced this event within each treatment group