Figure 3.

Weighted clinical improvement over time

(A–C) Kaplan-Meier curves for the three main primary treatment groups showing time to one-point improvement in clinical severity on ordinal scale weighted by inverse probability of treatment, for all patients (A), a subgroup of patients needing at least one of inotropes or ventilation at baseline (B), and a subgroup of patients not requiring inotropes or ventilation at baseline (C). Tables below the Kaplan-Meier curves show the numbers at risk at the start of each day, and the number censored at this specific time point. (D) Clinical severity on ordinal scale, shown as proportional column charts from 2 days before treatment to 10 days after treatment, separated by primary treatment group, and weighted by inverse probability of treatment. Additional groups have been added for graphical purposes. CRP=C-reactive protein. ECMO=extracorporeal membrane oxygenation.