Table 3.
Associations between viral burden rebound and study outcomes
|
Molnupiravir (n=563) |
Nirmatrelvir–ritonavir (n=242) |
Control (n=3787) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Patients, n/N* | % or OR (95% CI) | p value | Patients, n/N* | % or OR (95% CI) | p value | Patients, n/N* | % or OR (95% CI) | p value | ||
| Composite outcome† | 112/558 | 20·1% (16·7–23·4) | NA | 36/240 | 15·0% (10·5–19·5) | NA | 1103/3736 | 29·5% (28·1–31·0) | NA | |
| With viral burden rebound | 6/27 | 22·2% (5·5–39·0) | .. | 8/15 | 53·3% (24·7–81·9) | .. | 61/167 | 36·5% (29·1–43·9) | .. | |
| Without viral burden rebound | 106/531 | 20·0% (16·6–23·4) | .. | 28/225 | 12·4% (8·1–16·8) | .. | 1042/3569 | 29·2% (27·7–30·7) | .. | |
| Adjusted OR | .. | 1·05 (0·39–2·84) | 0·92 | .. | 1·90 (0·48–7·59) | 0·36 | .. | 1·27 (0·89–1·80) | 0·18 | |
| Mortality | 106/563 | 18·8% (15·6–22·1) | NA | 33/242 | 13·6% (9·3–18·0) | NA | 1029/3787 | 27·2% (25·8–28·6) | NA | |
| With viral burden rebound | 5/27 | 18·5% (2·9–34·2) | .. | 8/16 | 50·0% (22·5–77·5) | .. | 55/170 | 32·4% (25·2–39·5) | .. | |
| Without viral burden rebound | 101/536 | 18·8% (15·5–22·2) | .. | 25/226 | 11·1% (6·9–15·2) | .. | 974/3617 | 26·9% (25·5–28·4) | .. | |
| Adjusted OR | .. | 0·88 (0·30–2·55) | 0·81 | .. | 2·62 (0·67–10·25) | 0·17 | .. | 1·18 (0·82–1·69) | 0·37 | |
| ICU admission or invasive mechanical ventilation initiation | 11/558 | 2·0% (0·8–3·1) | NA | 8/240 | 3·3% (1·0–5·6) | NA | 190/3736 | 5·1% (4·4–5·8) | NA | |
| With viral burden rebound | 1/27 | 3·7% (0·0–11·3) | .. | 3/15 | 20·0% (0·0–42·9) | .. | 12/167 | 7·2% (3·2–11·1) | .. | |
| Without viral burden rebound | 10/531 | 1·9% (0·7–3·0) | .. | 5/225 | 2·2% (0·3–4·2) | .. | 178/3569 | 5·0% (4·3–5·7) | .. | |
| Adjusted OR | .. | 2·67 (0·29–24·22) | 0·38 | .. | 3·35 (0·35–32·49) | 0·30 | .. | 1·25 (0·66–2·35) | 0·49 | |
The baseline covariables of age, sex, pre-existing morbidities, vaccination status, concomitant treatments initiated, and Ct value on admission were considered in the adjusted regression model. OR=odds ratio. NA=not applicable. ICU-intensive care unit.
*
Patients with the outcome during the first 4 days from the index date were excluded from the analysis.
†
Composite outcome includes mortality, ICU admission, and initiation of invasive mechanical ventilation.