Table 1.
Antiviral activity of RDV against a broad panel of infectious human viruses.
| Viral family | Virus (strain) [cells] | Antiviral activity EC50 (µM)a | CC50 (µM) | Selectivity index (SI)b | Previously reported activity EC50 (µM) |
|---|---|---|---|---|---|
| Corona- | OC43 [Huh-7] | 0.067 ± 0.005 | 18.9 ± 1.8 | 282 | 0.096–0.1516,17 |
| 229E [H1 HeLa] | 0.093 ± 0.053 | > 50 | > 538 | 0.02418 | |
| Picorna- | Enterovirus 68D [RD] | 0.050 (n = 1) | 2.82 | 56 | 0.1–18 |
| Enterovirus 71 [RD] | 0.140 (n = 1) | 3.31 | 24 | NA | |
| Rhinovirus A2 [H1 HeLa] | 0.450 (n = 1) | > 10 | > 22 | NA | |
| Rhinovirus 14 [H1 HeLa] | 0.385 ± 0.318 | > 26 | |||
| Rhinovirus 16 [H1 HeLa] | 0.750 (n = 1) | > 13 | |||
| Flavi- | Dengue 1 virus (Western Pacific) [Huh-7] | 0.21 (n = 1) | 33.4 | 159 | NA |
| Dengue 1 virus (Djibouti) [Huh-7] | 0.31 ± 0.09 | 108 | |||
| Dengue 2 virus (New Guinea C) [Huh-7] | 0.23 (n = 1) | 145 | |||
| Dengue 2 virus (RL) [Huh-7] | 0.29 ± 0.07 | 115 | |||
| Dengue 3 virus (VN32) [Huh-7] | 0.12 (n = 1) | 278 | |||
| Dengue 3 virus (H87) [Huh-7] | 0.17 ± 0.07 | 196 | |||
| Dengue 4 virus (MY01) [Huh-7] | 0.18 (n = 1) | 186 | |||
| Dengue 4 virus (Dakar_HD_34460) [Huh-7] | 0.19 ± 0.05 | 176 | |||
| Zika virus (PRVABC59) [Huh-7] | 0.26 (n = 1) | 33.4 | 128 | NA | |
| Zika virus (Dakar) [Huh-7] | 0.37 (n = 1) | 90 | |||
| Zika virus (MR766) [Huh-7] | 1.15 ± 0.03 | 29 | |||
| Yellow fever virus (YFS11) [Huh-7] | 1.06 (n = 1) | 33.4 | 32 | NA | |
| Yellow fever virus (17D) [Huh-7] | 0.18 ± 0.03 | 186 | |||
| Japanese encephalitis (14–14-2) [Huh-7] | 0.34 (n = 1) | 33.4 | 98 | NA | |
| West Nile (NY99) [Huh-7] | 0.05 (n = 1) | 33.4 | 668 | NA | |
| Filo- | Ebola virus (Makona) [HeLa] | 0.078 ± 0.004 | > 2.5 | > 32 | 0.003–0.1410,13 |
| Ebola virus (Mayinga) [Hela] | 0.136 ± 0.017 | > 18 | |||
| Ebola virus (Kikwit) [HeLa] | 0.070 ± 0.008 | > 36 | |||
| Bundibugyo virus [Hela] | 0.19 ± 0.02 | > 10 | > 53 | NA | |
| Sudan virus (Gulu)[HeLa] | 0.06 (n = 1) | > 11.5 | > 192 | NA | |
| Sudan virus (Boneface) [HeLa] | 0.12 (n = 1) | > 2.5 | > 21 | ||
| Sudan virus (Yambio) [HeLa] | 0.13 (n = 1) | > 2.5 | > 19 | ||
| Marburg virus (Ci67) [HeLa] | 0.030 ± 0.002 | > 2.5 | > 83 | 0.01–0.0213 | |
| Marburg (Musoke) [HeLa] | 0.04 ± 0.004 | > 2.5 | > 63 | NA | |
| Marburg (Kabale) [HeLa] | 0.04 ± 0.002 | > 2.5 | > 63 | NA | |
| Marburg (Nganda) [HeLa] | 0.024 ± 0.004 | > 2.5 | > 104 | NA | |
| Marburg (Drandema) [HeLa] | 0.034 ± 0.004 | > 2.5 | > 74 | NA | |
| Marburg (Angola) [HeLa] | 0.045 ± 0.03 | > 2.5 | > 56 | NA | |
| Ravn Virus [HeLa] | 0.068 ± 0.01 | > 2.5 | > 37 | NA | |
| Hepaci- | Hepatitis C (1b) [Huh-7-lunet], replicon | 0.089 ± 0.047 | > 20 | > 225 | 0.05711 |
| Hepatitis C (2a) [Huh-7-lunet], replicon | 0.072 ± 0.013 | 17 ± 3 | 236 | NA | |
| Orthomyxo- | Influenza A (A/California/07/2009) [MDCK] | > 50 | > 100 | Low | NA |
| Influenza B (B/Brisbane/60/2008) [MDCK] | >50 | Low | |||
| Hepadna- | Hepatitis B (HepG2) | 3.9 to > 10 | 7.4 | Low | NA |
| Hepatitis B (PHH) | > 1 | > 1 | Low | ||
| Hepatitis D (Huh7-NTCP) | > 5 | 8–10 | Low | NA | |
| Hepatitis E GT3 Kernow C1 p6/Luc replicon [Huh-7] | > 2.07 | 2.07 | Low | NA |
NA data is not available.
aUnless noted, EC50 values are average ± standard deviation from at least 2–3 independent measurements. The studies marked n = 1 contain 2–4 technical replicates. For ease of comparison, literature values are listed when applicable. However, different cells and/or different assay protocols were used to generate the literature values.
bSelectivity Index = CC50/EC50. When minimal RDV antiviral activity is observed for a particular virus, low SI is indicated.