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. 2023 Feb 23;13:3131. doi: 10.1038/s41598-023-29517-9

Table 2.

Combination of RDV and favipiravir has additive effect on the antiviral activity against SUDV and MARV infections in cells, as shown by the combination index (CI), excess volume, and synergy score values.

Viruses Minimum CI Median CI Maximum CI Synergy model Excess volume Synergy score
SUDV 0.57 1.12 1.34 Loewe Model − 0.52 − 0.06
HSA Model 0.72 0.57
Bliss Model − 0.78 − 0.23
MARV 0.88 1.02 1.09 Loewe Model − 0.45 − 0.29
HSA Model 0.87 0.53
Bliss Model 0.02 − 0.08

CI combination index, HSA highest single agent.