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. 2022 Nov 7;28(1-2):20–38. doi: 10.1007/s10495-022-01780-7

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Fig. 2 — Potential strategies targeting the intrinsic apoptotic pathway either by directly targeting the pro-apoptotic or the pro-survival BCL-2 family members or by targeting metabolic pathways and signal transducers to induce apoptosis by causing an increase in pro-apoptotic BH3-only proteins and/or a decrease in the pro-survival BCL-2 family members