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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: Am J Obstet Gynecol. 2022 Aug 24;228(3):334.e1–334.e21. doi: 10.1016/j.ajog.2022.08.041

Table 2.

Descriptions of fetal growth phenotypes identified by univariate and multivariate latent class trajectory models in the LIFECODES Fetal Growth Study.

Univariate trajectory groups

Group Name Description

1 Extremely Small Has modest consistent increase in growth rate, but overall, the smallest relative EFW from mid- to late pregnancy.
2 Small Exhibits an increase in relative EFW during mid-pregnancy. Growth rate stabilizes in late pregnancy and relative size remains small (e.g., close to 10th percentile).
3 Average-Declining EFW within normal range throughout, but growth rate declines after approximately 30 weeks gestation.

Multivariate trajectory groups

Group Name Description

1 Extremely Small Smallest relative size of HC, AC, FL from mid- to late pregnancy with constant growth rate.
2 Small-Asymmetric HC:AC Growth within normal range in mid-pregnancy. Relative HC normal through late pregnancy, but AC and FL growth rate slows across pregnancy.
3 Small-Symmetric HC:AC All growth parameters within small or normal range from mid- to late-pregnancy. Stable growth rate from mid- to late pregnancy.
4 Average-Declining Normal HC, AC, and FL size throughout, but growth rate slows across pregnancy for all measures of growth.