Understanding treatment burden in hemophilia: development and validation of the Hemophilia Treatment Experience Measure (Hemo-TEM)

	1a	1b	1c	1d	1e	2a	2b	3a	3b	3c	3d	3e	3f
1a diff good place to inject	1.000
1b diff put needle correctly	.718^b	1.000
1c diff find good place	.553	.644	1.000
1d diff remember^a	.077	.242	.240	1.000
1e diff exactly as instructed^a	.242	.241	.390	.541	1.000
2a often postpone on purpose	.117	.186	.279	.203	.300	1.000
2b often postpone accident^a	-.118	.091	.068	.381	.341	.363	1.000
3a often soreness	.253	.153	.209	.090	.162	.230	.189	1.000
3b often physical discomfort	.295	.245	.306	.036	.254	.304	.234	.683	1.000
3c often pain	.270	.181	.233	.095	.200	.132	.290	.622	.685	1.000
3d often bruising	.384	.282	.359	-.077	.046	.194	.110	.452	.387	.510	1.000
3e often ruptured veins	.389	.310	.264	.082	.060	.100	-.028	.394	.364	.324	.412	1.000
3f often probs scarring	.384	.303	.304	.117	.182	.089	.174	.513	.479	.524	.467	.469	1.000
4a bother number steps	.267	.209	.324	.186	.283	.323	.259	.238	.290	.288	.337	.205	.287
4b bother amt of time to prepare/give	.268	.259	.341	.265	.348	.409	.295	.196	.081	.201	.312	.146	.207
4c bother store meds	.231	.211	.475	.068	.171	.377	.165	.231	.063	.115	.329	.139	.282
4d bother carry meds	.294	.302	.485	.219	.275	.327	.233	.277	.161	.265	.420	.199	.349
4e bother often give treatment	.311	.270	.339	.234	.236	.461	.212	.240	.193	.263	.306	.246	.347
4f bother find time	.280	.284	.479	.277	.308	.431	.243	.269	.223	.228	.316	.250	.395
5a interfere travel/vacation	.442	.416	.545	.139	.270	.349	.129	.258	.253	.242	.485	.329	.383
5b interfere social acts	.277	.258	.463	.166	.311	.428	.241	.345	.393	.336	.377	.200	.330
5c interfere daily acts	.218	.146	.332	.253	.374	.325	.193	.361	.350	.242	.182	.175	.277
5d interfere work/school	.253	.138	.383	.190	.301	.340	.133	.443	.307	.257	.250	.350	.231
6a often anxious	.295	.297	.404	.173	.273	.313	.234	.344	.519	.363	.471	.375	.328
6b often frustrated	.363	.266	.349	.141	.269	.297	.214	.310	.384	.311	.464	.317	.444
6c often stressed	.196	.104	.248	.139	.342	.395	.137	.224	.385	.275	.431	.184	.224
6d often embarrassed^a	.069	.138	.340	.302	.319	.307	.340	.228	.332	.273	.372	.291	.279
6e often worried infection	.247	.046	.183	.143	.242	.131	.153	.327	.446	.448	.230	.250	.300
6f often worried develop inhibitor	.141	.040	.236	-.063	.109	.147	.163	.469	.534	.485	.309	.276	.362
6g often worried losing access vein	.597	.595	.531	.025	.210	.164	.001	.386	.453	.419	.470	.613	.514

	4a	4b	4c	4d	4e	4f	5a	5b	5c	5d
4a bother number steps	1.000
4b bother amt of time to prepare/give	.679	1.000
4c bother store meds	.384	.527	1.000
4d bother carry meds	.280	.511	.690	1.000
4e bother often give treatment	.497	.578	.458	.544	1.000
4f bother find time	.357	.519	.597	.719^b	.653	1.000
5a interfere travel/vacation	.385	.488	.627	.651	.550	.556	1.000
5b interfere social acts	.513	.451	.457	.497	.606	.497	.690	1.000
5c interfere daily acts	.410	.363	.325	.437	.507	.483	.587	.773^b	1.000
5d interfere work/school	.372	.283	.379	.434	.389	.590	.530	.629	.702^b	1.000
6a often anxious	.488	.393	.406	.379	.453	.407	.506	.506	.421	.318
6b often frustrated	.432	.499	.436	.489	.517	.494	.600	.513	.459	.317
6c often stressed	.417	.448	.370	.392	.439	.432	.516	.558	.430	.269
6d often embarrassed^a	.423	.370	.428	.465	.355	.442	.455	.499	.491	.314
6e often worried infection	.253	.090	.115	.210	.153	.146	.230	.222	.198	.240
6f often worried develop inhibitor	.195	.112	.195	.200	.142	.212	.296	.312	.210	.333
6g often worried losing access vein	.315	.331	.277	.363	.391	.262	.495	.413	.289	.293

	6a	6b	6c	6d	6e	6f	6g
6a often anxious	1.000
6b often frustrated	.696	1.000
6c often stressed	.666	.690	1.000
6d often embarrassed	.647	.528	.576	1.000
6e often worried infection	.369	.239	.283	.318	1.000
6f often worried develop inhibitor	.347	.259	.314	.297	.617	1.000
6g often worried losing access vein	.510	.468	.300	.247	.276	.393	1.000

Table 5.