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UCH-L1 balances EGFR expression. UCH-L1 deubiquitinates and regulates levels of EGFR, further activating MAPK signaling. Over-activated MAPK signaling downregulates ER or induces expression of P-gp, CD147 and MDR1. ER, estrogen receptor; MDR1, multidrug resistance protein 1; P-gp, P-glycoprotein; Ub, ubiquitin; UCH-L1, Ub C-terminal hydrolase-L1.
