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UCH-L1 induces PEM resistance in NSCLC. Overexpressed UCH-L1 regulates Cyclin E and c-myc by upregulating TS in NSCLC cells. High levels of Cyclin E and c-myc promote DNA repair and inhibit apoptosis, thereby alleviating PEM-induced DNA destruction and cell cycle disorder in NSCLC cells. NSCLC, non-small cell lung cancer; PEM, pemetrexed; TS, thymidylate synthase; UCH-L1, ubiquitin C-terminal hydrolase-L1.
