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. 2023 Feb 10;10:1129831. doi: 10.3389/fmolb.2023.1129831

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Copyright © 2023 Kohlhepp, Liu, Tacke and Guillot.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Macrophage-centered view on the molecular mechanisms implicated in NAFLD and HCC pathogenic pathways. Liver macrophages are involved in virtually all NAFLD and HCC-related pathogenic signaling pathways, giving them a central role of disease course orchestrators, with sometimes contradictory beneficial and detrimental functions. Abbreviations, CCRs, chemokine receptors; DAMPs, damage-associated molecular patterns; EMT: epithelial-mesenchymal transition; HSC, hepatic stellate cell; KC, Kupffer cell; IL, interleukin; MFB, myofibroblast; PAMPs, pathogen-associated molecular patterns; ROS, reactive oxygen species; TLRs, toll-like receptors. Created with BioRender.com.