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. 2022 Dec 16;30(2):515–526. doi: 10.1038/s41418-022-01101-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Experimental timeline used for lineage tracing of myoepithelial cells upon deletion of ΔNp63. Animals were administered TAM to simultaneously induce ΔNp63 specific deletion in the MECs and irreversibly label MECs with RFP expression. Animals were traced for 1 month and SMGs were analyzed. Immunostaining of the B male and C female control and ΔNp63MECcKORFP glands. Arrows indicate co-localization of RFP-positive cells with various epithelial cell markers. Myoepithelial: SMA, ΔNp63, Ductal: K7, Sox9, Acinar: Mist1. Scale bar: 50 µm.