Fig. 4. Anti-tumorigenic immune response upon MOMP-induced immunogenic cell death in tumours.

Induction of immunogenic cell death in cancer cells can be achieved through MOMP in combination with caspase inhibition. Activation of several cell autonomous immune signalling pathways leads to the transcription and release of type I interferons and NF-κB target genes. Release of cytokines and chemokines recruits and activates anti-tumour T cells, macrophages and neutrophils thereby enhancing cancer cell death and tumour regression.