Table 2.

Independent variables after survival analysis (Cox regression).

	Diffuse type gastric cancer						Intestinal type gastric cancer
	Overall survival			Tumor specific survival			Overall survival
	HR	95% CI	p Value	HR	95% CI	p Value	HR	95% CI	p Value
Stage			< 0.001			< 0.001			0.002
II versus I	3.290	0.761–14.218	0.111	5.877	0.775–44.590	0.087	2.511	1.411–4.470	0.002
III versus I	7.240	1.745–30.036	0.006	15.231	2.072–112.0	0.007	2.679	1.427–5.030	0.002
IV versus I	9.557	2.225–41.056	0.002	19.337	2.581–144.9	0.004	3.828	1.855–7.900	< 0.001
LNR (high vs. low)							2.149	1.351–3.420	0.001
pV (V1 vs. V0)	2.268	1.014–5.071	0.046
pR (R1/R2 vs. R0)	3.030	1.731–5.302	< 0.001	3.160	1.811–5.512	< 0.001	2.558	1.406–4.655	0.002
HER2 status (positive vs. negative)	4.238	1.493–12.032	0.007	3.767	1.330–10.670	0.013
FZD7 status							1.567	1.126–2.180	0.008
RNF43 (low vs. high)	2.393	1.333–3.226	0.001	2.398	1.488–3.861	< 0.001

Included were all variables having p < 0.100 in univariate survival analysis (log-rank test), i.e., UICC stage, lymph node ratio, L category, V category, R status, HER2-status, and RNF43 for diffuse subgroup, and UICC stage, lymph node ratio (LNR), L category, R status, FZD7 status, and RNF43 for intestinal subgroup.