TABLE 2.

Inducers and inhibitors of Sirt-1.

Number	Name	Data source	References
Sirt1 inducers
1	Resveratrol	A review	Bhullar and Hubbard (2015)
2	Salvianolic acid	A rat model of chronic alcoholic liver disease	Zhang et al. (2017b)
3	Quercetin	A rat model of osteoarthritis	Qiu et al. (2018)
4	Fisetin	3T3-L1 cells model	Kim et al. (2015)
5	Panaxtriol saponins	PC12 cells and zebrafish	Zhang et al. (2017a)
6	Ginsenoside Rg3	Aged rats model	Yang et al. (2018)
7	Ginsenoside Rb2	H9C2 cell line	Huang et al. (2019)
8	Ginsenoside Rc	HEK293T cell line	Kim et al. (2014)
9	Ophiopogonin D	H9c2 cell line	Wang et al. (2016)
10	SRT1720	Obese mice model	Minor et al. (2011)
11	Strigolactone analogue GR24	Rat L6 skeletal muscle cell line	Modi et al. (2017)
12	SIRT1460	Obese mice model	Milne et al. (2007)
13	SRT2183	sirt1−/− mice model	Gurt et al. (2015)
14	A03	Alzheimer’s disease mouse model	Campagna et al. (2018)
15	MHY2233	db/db mice model	Kim et al. (2018)
16	SRT2104	Clinic trial	Lin et al. (2019)
17	SRT3025	Clinic trial	Venkatasubramanian et al. (2013)
Sirt1 inducers
1	Sirtinol	Rats model	Safari et al. (2017)
2	cambinol	RPMI8226 and U266 cells	Lu et al. (2021a)
3	inauhzin	HCT116 and DLD1 cells	Sun et al. (2022b)
4	EX527	U87MG and LN-299 glioma cell lines	Wang et al. (2020a)
5	AGK2	A549 and H1299 non-small cell lung cancer cells	Ma et al. (2018)
6	Suramin	Structure–activity Study	Trapp et al. (2007)
7	Tenovin	HCT116 cells	Ueno et al. (2013)
8	Salermide	BxPC-3 pancreatic cancer cell line	Yar Saglam et al. (2016)