PER2 interacting proteins.A, nuclear extracts prepared from mouse liver at ZT19 were immunoprecipitated with anti-PER2 antibodies. The volcano plot was prepared as in Figure 3A. B, volcano plot comparing binding ratios as a function of p values for proteins detected in wildtype versus Per1/2−/− mouse liver nuclear extracts. C, Venn diagram showing overlap of significant PER interacting proteins between the two approaches (PER2 WT versus IgG, PER2 WT versus KO) and the two repeats of each approach (R1, R2). D, interactive network of the 13 common interacting proteins identified in (C), generated by STRING.