Fig. 5.

The pathways and molecular docking diagrams of berberine with the key targets. CDK2, cyclin-dependent kinase 2; EGFR, estimated glomerular filtration rate; ENO1, enolase 1; ERK, extracellular signal-regulated kinase; Grb2, growth factor receptor-bound protein 2; FOXO, forkhead box O; HIF-1, hypoxia-inducible factor 1; IKBKB, inhibitor of nuclear factor kappa-B kinase subunit β; IL6-R, interleukin-6 receptor; INS, insulin preproprotein; IRS, insulin receptor substrate; NFkB, nuclear factor kappa B; PLK, polo-like kinase-1; RAS, renin-angiotensin system; TAB1, TAK1-binding protein 1; TAK1, TGF-activated kinase 1; SOS, salt overly sensitive; STAT3, signal transducer and activator of transcription 3.