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. 2023 Feb 1;12(2):91–102. doi: 10.1302/2046-3758.122.BJR-2022-0269.R1

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© 2023 Author(s) et al.

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Fig. 6 — The binding energies for the key targets docked into the berberine. a) AKT2-berberine (-9.1); b) AKT3 -berberine (-7.0); c) cyclin-dependent kinase 2 (CDK2)-berberine (-10.1); d) enolase 1 (ENO1)-berberine (-7.1); e) forkhead box 3 (FOXO3)-berberine (-8.9); f) FOXO4-berberine (-9.0); g) hypoxia-inducible factor 1 alpha (HIF-1α)-berberine (-6.0); h) HRAS-berberine (-7.3); i) inhibitor of nuclear factor kappa-B kinase subunit β (IKBKB)-berberine (-7.7); j) mitogen-activated protein kinase 1 (MAPK1)-berberine (-9.1); k) polo-like kinase-1 (PLK1)-berberine (-9.0); l) PLK4-berberine (-6.6); and m) signal transducer and activator of transcription 3 (STAT3)-berberine (-7.9).