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. 2023 Feb 10;13:991483. doi: 10.3389/fonc.2023.991483

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Copyright © 2023 Jiang, Tang, Zhang, He, Xie, Tang, Liu, Luo, Lu, Liu, Lu, He and Wei

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Filtered DEGs and GNG4 expression in OS. (A, B) The DEGs between normal and tumour samples of GSE12865 and GSE14359. The significant differences between the two groups are shown in the form of volcanic maps. (C, D) The G protein family genes were intersected with upregulated and downregulated genes in the two GEO datasets to obtain a Venn diagram of the intersected genes (upregulated GNG4 and downregulated GNG12). (E, G) GNG4 expression in OS in the integrated GEO dataset and GTEx + TARGET dataset, respectively. (F, H) The diagnostic ROC curve of GNG4 in the integrated GEO dataset and GTEx + TARGET dataset, respectively. (I) Differential expression of GNG4 in pancancer tissues. ***p<0.001, **p<0.01, *p≤0.05, and ns, p>0.05.