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. 2023 Feb 10;13:991483. doi: 10.3389/fonc.2023.991483

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Copyright © 2023 Jiang, Tang, Zhang, He, Xie, Tang, Liu, Luo, Lu, Liu, Lu, He and Wei

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DEGs analysis of high- and low-GNG4 expression clusters. GO and GSEA functional enrichment analyses of GNG4, the PPI network, and hub gene cluster construction. (A, B) Grouped in accordance with the median GNG4 value in the TARGET dataset, a total of 224 significantly different genes were screened, including 127 upregulated and 97 downregulated genes. (C) The GO enrichment method was used to analyse the differentially expressed genes in the high- and low-GNG4 expression clusters. The bubble size represents the amount of gene concentration, and the colour represents the significance of the difference. (D) GSEA showed enriched genes involved in “ECM degradation,” “collagen,” “ECM glycoprotein,” “focal adhesion,” and “cell cycle” signalling pathways. (E) PPI networks from the TARGET dataset. (F) Five hub gene clusters were obtained from the TARGET dataset by using the MCODE clustering algorithm.