Table 4.
Univariable and multivariable Cox regression analysis of clinical characteristics and GNG4 in the external validation cohort.
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | P value | HR | 95%CI | P value | |
| GNG4 | 9.37 | 3.1-28.28 | 0.00007 | 10.97 | 2.43-49.43 | 0.002 |
| Positive | ||||||
| Negative | ||||||
| Age | 1.42 | 0.59-3.43 | 0.43764 | |||
| >16 years | ||||||
| ≤16 years | ||||||
| Gender | 0.76 | 0.31-1.83 | 0.53589 | |||
| Female | ||||||
| Male | ||||||
| Relapse | 5.65 | 2.3-13.91 | 0.00016 | 1.25 | 0.36-4.35 | 0.726 |
| Yes | ||||||
| No | ||||||
| Metastasis | 10.69 | 3.54-32.22 | 0.00003 | 15.94 | 1.55-163.61 | 0.02 |
| Yes | ||||||
| No | ||||||
| TNM stage | 0.15 | 0.05-0.41 | 0.00023 | 3.35 | 0.42-26.77 | 0.253 |
| I | ||||||
| II/III | ||||||
| Location | 0.49 | 0.18-1.36 | 0.17094 | |||
| Femur/Tibia | ||||||
| Else | ||||||
| Tumor size | 0.49 | 0.2-1.23 | 0.12952 | |||
| >6 cm | ||||||
| ≤6 cm | ||||||
Values in bold indicate a P value less than 0.05, indicating a statistically significant difference.