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. 2023 Feb 14;2023:1744102. doi: 10.1155/2023/1744102

Figure 2.

Figure 2

LINC00578 promotes pancreatic cancer cell proliferation and invasion in vitro and tumor growth in vivo. (a) CCK-8 assays were applied to detect cell viability at the indicated time points in PATU8988 cells transfected with LINC00578 (OE-LINC00578) versus empty vector-transfected PATU8988 cells (Vector) and LINC00578 knockdown PL45 cells (Sh-LINC00578) versus empty vector knockdown PL45 cells (Sh-NC). (b) Colony formation assays were applied to detect cell proliferation in PATU8988 cells (OE-LINC00578 group versus vector group) and PL45 cells (Sh-LINC00578 group versus Sh-NC group). (c) Wound-healing assay indicating LINC00578-induced increased migration in PATU8988 and PL45 cells. (d) Tumor size, volume, and weight at day 30 after subcutaneous injection of LINC00578-overexpressing PATU8988 cells (n = 6) compared with the vector group (n = 6). (e) A nucleocytoplasmic separation assay was used to determine the intracellular location of LINC00578 in PATU8988 cells and PL45 cells. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001.