Table 3.
Results of mixed-effects model with time point, cannabis exposure during pregnancy, and their interactions as independent variables for the brain volumes.
| Unstandardized |
Standardized |
R squared | p value | FDR p-value | |||||
|---|---|---|---|---|---|---|---|---|---|
| coefficients | 95% CI |
coefficients | 95% CI |
||||||
| lower | upper | lower | upper | ||||||
| Without covariate | |||||||||
| Intracranial volume | |||||||||
| Time | 29,683.910 | 28,814.313 | 30,553.508 | 0.101 | 0.098 | 0.104 | 0.011 | < .001 | < .001 |
| Cannabis | -19,360.978 | -30,063.711 | -8658.244 | -0.035 | -0.052 | -0.018 | < .001 | 0.001 | |
| Time: Cannabis | -4938.278 | -8470.297 | -1406.259 | -0.004 | -0.007 | -0.001 | 0.006 | 0.008 | |
| White matter volume | |||||||||
| Time | 5869.002 | 5590.628 | 6147.376 | 0.057 | 0.055 | 0.060 | 0.639 | < .001 | < .001 |
| Cannabis | -2637.851 | -4638.176 | -637.525 | -0.011 | -0.020 | -0.002 | 0.01 | 0.012 | |
| Time: Cannabis | 582.143 | -485.575 | 1649.861 | 0.001 | -0.001 | 0.004 | 0.285 | 0.285 | |
| Gray matter volume | |||||||||
| Time | -20,796.640 | -21,232.186 | -20,361.094 | -0.152 | -0.155 | -0.149 | 0.675 | < .001 | < .001 |
| Cannabis | -6529.182 | -8947.759 | -4110.606 | -0.021 | -0.029 | -0.012 | < .001 | < .001 | |
| Time: Cannabis | 1262.279 | -443.614 | 2968.171 | 0.002 | -0.001 | 0.005 | 0.147 | 0.162 | |
| With covariate | |||||||||
| Intracranial volume | |||||||||
| Time | 29,939.517 | 28,904.834 | 30,974.200 | 0.102 | 0.098 | 0.105 | 0.271 | < .001 | < .001 |
| Cannabis | 2688.782 | -11,613.667 | 16,991.232 | -0.000 | -0.023 | 0.023 | 0.713 | 0.773 | |
| Time: Cannabis | -6338.309 | -11,066.588 | -1610.029 | -0.005 | -0.009 | -0.001 | 0.009 | 0.019 | |
| White matter volume | |||||||||
| Time | 7729.754 | 7436.208 | 8023.300 | 0.075 | 0.072 | 0.078 | 0.616 | < .001 | < .001 |
| Cannabis | -3036.717 | -6458.079 | 384.646 | -0.014 | -0.029 | 0.002 | 0.082 | 0.148 | |
| Time: Cannabis | 175.226 | -1013.692 | 1364.144 | 0.000 | -0.002 | 0.003 | 0.773 | 0.773 | |
| Gray matter volume | |||||||||
| Time | -19,359.974 | -19,848.143 | -18,871.805 | -0.141 | -0.145 | -0.138 | 0.727 | < .001 | < .001 |
| Cannabis | 2839.766 | -760.075 | 6439.608 | 0.012 | -0.001 | 0.024 | 0.122 | 0.183 | |
| Time: Cannabis | 1035.433 | -1065.623 | 3136.489 | 0.002 | -0.002 | 0.005 | 0.334 | 0.43 | |
Note. The FDR was corrected for the three (Time, Cannabis, and Time: Cannabis) x three (ICV, WMV, and GMV).