Fig. 7.

Micrographs demonstrating histopathological changes in groups under investigation using light microscopy and determination of the mean morphometric analysis of epidermal layer thickness that expressed as mean ± SD * Statistically significantly different from the non-irradiated negative control group (P < 0.05); @ Statistically significantly different from the model-irradiated positive control group (P < 0.05); # Statistically significantly different from the CAF-GEL group (P < 0.05); $ Statistically significantly different from the blank HS group (P < 0.05).

Normal control (A&B), Model samples (C&D), CAF-GEL Samples (E&F), HS_blank samples (G&H) and caffeinated hyalurosomes samples (I&J). Epidermis (black arrow), inflammatory cells (red arrow) and Congested BVs (arrow head). H&E stain, 100× & 400×. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)