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. 2022 Nov 10;14(9):mjac061. doi: 10.1093/jmcb/mjac061

Figure 2.

Figure 2

FTO promotes liver TG accumulation by increasing lipogenesis. (A and B) Relative mRNA levels of lipogenic genes and representative protein levels of FASN and ACC1 in the liver of mice (A, n = 3) or HFD-fed mice (B, n = 3) infected with Ad-Ctrl or Ad-FTO. (C and D) Relative mRNA levels of genes related to fatty acid oxidation (CPTIα and PPARα) and uptake (CD36) and VLDL exportation (APOB and MTTP) in the liver of mice (C, n = 6) or HFD-fed mice (D, n = 3) infected with Ad-Ctrl or Ad-FTO. (E and F) Relative mRNA levels of lipogenic genes and representative protein levels of FASN and ACC1 in HepG2 cells (E, n = 3) or primary hepatocytes (F, n = 3) infected with Ad-FTO or Ad-Ctrl. Data shown are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. NS denotes not significant.