TABLE 1.
Metabolic phenotypes of Foar mutations
| Straina | MIC of FOA (μg/ml) | ODCase activityb
|
|
|---|---|---|---|
| U/g of protein | % of control | ||
| DG6 | 8 | 4.7 ± 2.8 | 86 |
| DG40 | 8 | 6.4 ± 0.2 | 117 |
| DG55 | 8 | 5.3 ± 0.3 | 97 |
| MR30 | ≥1,600 | 1.6 ± 1.5 | 29 |
| MR31 | ≥1,600 | 9.9 ± 0.4 | 181 |
| MR72 | ≥1,600 | 10.4 ± 4.9 | 190 |
| MR103 | ≥1,600 | 0.6 ± 0.4 | 11 |
| MR146 | ≥1,600 | 0.8 ± 0.3 | 15 |
| MR362 | ≥1,600 | 12.7 ± 2.1 | 232 |
| MR367 | 200 | 11.0 ± 2.1 | 201 |
| MR402 | 200 | 14.9 ± 7.6 | 273 |
| MR405 | 200 | 10.4 ± 4.6 | 190 |
a
DG6 is the wild-type parent; see reference 5 for derivation of other strains.
b
Values are averages of two independent determinations ± ½ range. The control value is the average for the three Pyr+ strains (5.47 U/g of protein).