Figure 2.

a) Common photoactive ligands for MOF construction. b) Schematic illustration of using Fe–TBP to overcome hypoxia for PDT primed cancer immunotherapy. Reproduced with permission.^{[ 101 ]} Copyright 2018, American Chemical Society. c) Schematic illustration of the soft‐X‐ray‐responsive nanoprobe with the explosive generation of ROS for deep tissue synergistic PDT–immunotherapy of tumor and modulating the immunosuppressive TME. Reproduced with permission.^{[ 106 ]} Copyright 2021, Wiley‐VCH. d) Schematic illustration of the synthetic procedure of SMTA. e) Schematic illustration of the proposed mechanism of PIS‐mediated photodynamic immunotherapy. f) Schematic illustration of innate and adaptive immune coactivation by SMTA. Reproduced with permission.^{[ 109 ]} Copyright 2022, Wiley‐VCH.