Figure 3.

a) Schematic illustration of the smart biomimetic nanoplatform for antitumor chemo‐immunotherapy and immunometabolism normalization based on the ROS–ferroptosis–glycolysis regulation. Reproduced with permission.^{[ 119 ]} Copyright 2021, Elsevier. b) Schematic synthesis of MOF@GOx@MnO₂@PEG (MGMP) for ferroptosis‐based immunotherapy. MGMP disrupts redox and iron homeostasis to improve ferroptosis‐based immunotherapy through GSH depletion, ROS production, downregulation of transferrin 1, and PD‐L1 checkpoint block suppression. c) Schematic illustration of Apt‐PD‐L1 blocking immune checkpoint. Reproduced with permission.^{[ 120 ]} Copyright 2022, Elsevier.