Figure 18.

a) Schematic representation of noneven distribution of epitope spikes on the surface of a viral particle, and designed, virus‐mimicking DNA origami epitopes (DOEs) for IgG capture and binding. Reproduced with permission.^{[ 229 ]} Copyright 2020, Springer Nature. b) Engineering of polyplex‐nanoparticle‐coated Salmonella. Reproduced with permission.^{[ 230 ]} Copyright 2015, American Chemical Society. c) Gold nanoparticles functionalized with thiolated‐PEG—COOH conjugated to TAM‐targeting peptide (M2pep) and thiolated anti‐VEGF siRNA labeled with Alexa Fluor 488. d) Schematic of the outcome of the proposed combined silencing therapy (immunotherapy targeting TAMs and cancer cells) in vivo via highly specific and potent nanoparticles administered directly to bronchial airways. Reproduced with permission.^{[ 233 ]} Copyright 2015, Wiley‐VCH.