TABLE 5.
Multivariable logistic regression analysis of six tag SNPs in different age groups.
| SNP | Infants (<5 years) | Children (5–17 years) | ||||||
|---|---|---|---|---|---|---|---|---|
| Genetic model | Genotype | P a | OR (95%CI) a | Genetic model | Genotype | P a | OR (95%CI) a | |
| rs2280801 | Recessive | CC + CT | 1.00 | Dominant | CC | 1.00 | ||
| TT | .707 | 1.467(.198–10.859) | CT + TT | .152 | 2.469(.718–8.489) | |||
| rs10885 | Dominant | CC | 1.00 | Dominant | CC | 1.00 | ||
| CT + TT | .438 | 1.318(.656–2.647) | CT + TT | .336 | .441(.083–2.336) | |||
| rs1046089 | Dominant | GG | 1.00 | Recessive | GG + GA | 1.00 | ||
| GA + AA | .084 | .537(.265–1.088) | AA | .290 | .395(.071–2.210) | |||
| rs2736158 | Dominant | GG | 1.00 | Overdominant | GG + CC | 1.00 | ||
| GC + CC | .434 | 1.384(.614–3.119) | GC | .779 | 1.197(.342–4.187) | |||
| rs1046080 | Dominant | AA | 1.00 | Dominant | AA | 1.00 | ||
| AC + CC | .368 | .530(.133–2.111) | AC + CC | .999 | — | |||
| rs9366785 | Overdominant | GG + AA | 1.00 | Overdominant | GG + AA | 1.00 | ||
| GA | .019 | 2.934(1.198–7.184) | GA | .559 | 1.748(.269–11.352) | |||
| SNP | Adults (18-64 years) | The elderly (≥65years) | ||||||
|---|---|---|---|---|---|---|---|---|
| Genetic Model | Genotype | P a | OR (95%CI) a | Genetic Model | Genotype | P a | OR (95%CI) a | |
| rs2280801 | Dominant | CC | 1.00 | Overdominant | CC+TT | 1.00 | ||
| CT+TT | .051 | .592(.350-1.002) | CT | .631 | .820(.366-1.839) | |||
| rs10885 | Recessive | CC+CT | 1.00 | Overdominant | CC+TT | 1.00 | ||
| TT | .296 | 2.624(.429-16.045) | CT | .092 | .411(.146-1.158) | |||
| rs1046089 | Recessive | GG+GA | 1.00 | Dominant | GG | 1.00 | ||
| AA | .014 | .391(.185-.829) | GA+AA | .050 | .462(.214-.998) | |||
| rs2736158 | Overdominant | GG+CC | 1.00 | Recessive | GG+GC | 1.00 | ||
| GC | .292 | 1.367(.764-2.446) | CC | .999 | — | |||
| rs1046080 | Recessive | AA+AC | 1.00 | Overdominant | AA+CC | 1.00 | ||
| CC | 1.000 | — | AC | .274 | 3.633(.361-36.607) | |||
| rs9366785 | Recessive | GG+GA | 1.00 | Dominant | GG | 1.00 | ||
| AA | .137 | 5.642(.576-55.296) | GA+AA | .004 | 3.792(1.529-9.402) | |||
a
Adjusted for gender. SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.