Table 3.
Univariable and multivariable analyses for OS in the training cohort
| Univariable | Multivariable | |||||
|---|---|---|---|---|---|---|
| Variables | HR | 95%CI | P value | HR | 95%CI | P value |
| Age, year | 1.005 | 0.993–1.017 | 0.453 | |||
| Sex, male vs. female | 1.055 | 0.808–1.377 | 0.694 | |||
| Hepatolithiasis, yes vs. no | 1.266 | 0.824–1.945 | 0.282 | |||
| Diabetes, yes vs. no | 0.921 | 0.555–1.530 | 0.751 | |||
| HBsAg (+), yes vs. no | 0.816 | 0.633–1.052 | 0.116 | |||
| Anti-HCV, yes vs. no | 0.749 | 0.239–2.343 | 0.619 | |||
| Child-Pugh grade, B vs. A | 0.446 | 0.143–1.394 | 0.165 | |||
| TBIL, mg/dL | 0.999 | 0.993–1.005 | 0.761 | |||
| ALT, IU/L | 1.001 | 0.999–1.002 | 0.081 | |||
| AST, IU/L | 1.001 | 1.000-1.002 | 0.042 | |||
| GGT, IU/L | 1.001 | 1.000-1.002 | 0.011 | |||
| HgB, g/L | 0.991 | 0.984–0.998 | 0.009 | |||
| PT, second | 1.058 | 0.956–1.172 | 0.274 | |||
| ALB, g/L | 0.950 | 0.92–0.981 | 0.002 | |||
| PLT, ×109/L | 1.002 | 1.000-1.003 | 0.034 | |||
| WBC, ×109/L | 1.075 | 1.014–1.139 | 0.015 | |||
| AFP, µg/L | 1.000 | 0.999–1.001 | 0.615 | |||
| CEA, µg/L | 1.000 | 0.999–1.001 | 0.142 | |||
| CA19-9, IU/mL | 1.001 | 1.000-1.002 | < 0.001 | 1.000 | 1.0001–1.001 | 0.010 |
| Perioperative transfusion, yes vs. no | 1.354 | 0.974–1.883 | 0.071 | |||
| Anatomic resection, yes vs. no | 1.704 | 1.175–2.472 | 0.005 | 1.578 | 1.085–2.295 | 0.017 |
| Major resection, yes vs. no | 1.553 | 1.186–2.033 | 0.001 | |||
| Resection margin < 10 mm, yes vs. no | 1.833 | 1.134–2.963 | 0.012 | |||
| Cirrhosis, yes vs. no | 0.854 | 0.623–1.171 | 0.327 | |||
| Tumor diameter, cm | 1.117 | 1.074–1.162 | < 0.001 | |||
| Multiple tumors, yes vs. no | 0.816 | 0.433–1.538 | 0.530 | |||
| Satellite nodules, yes vs. no | 1.997 | 1.537–2.595 | < 0.001 | 1.448 | 1.095–1.915 | 0.009 |
| Tumor capsule, yes vs. no | 0.620 | 0.421–0.914 | 0.016 | |||
|
Tumor differentiation, high vs. median vs. low |
1.410 | 0.809–2.458 | 0.225 | |||
| Adjacent tissue invasion, yes vs. no | 1.570 | 0.944–2.611 | 0.082 | |||
| MVI, yes vs. no | 1.794 | 1.254–2.566 | 0.001 | 1.587 | 1.101–2.291 | 0.014 |
| LNM, yes vs. no | 2.179 | 1.618–2.935 | < 0.001 | 1.422 | 1.038–1.949 | 0.028 |
| IFS, high vs. median vs. low | 2.320 | 1.955–2.753 | < 0.001 | 2.106 | 1.682–2.637 | < 0.001 |
Abbreviations: HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; TBIL, total bilirubin; ALB, albumin; ALT, alanine transaminase; AST, aspartate aminotransferase; GGT, gamma-glutamyl transpeptidase; PT, prothrombin time; PLT, platelet; AFP, alpha-fetoprotein; CEA, carcinoembryonic antigen; CA19-9, carbonhydrateantigen19-9; MVI, microvascular invasion; LNM, lymph node metastasis; IFS, inflammation score