Table 3. Prevalence of comorbidity in COPD patients in the diagnosed COVID-19 cohort.
|
CU-AMC HDC
% (95%CI) |
CUIMC
% (95%CI) |
HealthVerity
% (95%CI) |
IQVIA-
OpenClaims % (95%CI) |
OptumEhr
% (95%CI) |
STARR-OMOP
% (95%CI) |
VA-OMOP
% (95%CI) |
CPRD
% (95%CI) |
IPCI
% (95%CI) |
SIDIAP
% (95%CI) |
LPD-FRANCE
% (95%CI) |
LPDItaly
% (95%CI) |
|
| Anxiety | 16.6 (14.0-19.6) | 11.4 (9.3-13.8) | 15.7 (14.8-16.6) | 15.9 (15.6-16.2) | 18.6 (17.9-19.3) | 21.1 (16.2-27.0) | 33.5 (32.7-34.3) | <1.9 | 8.0 (5.0-12.6) | 26.3 (25.6-27.0) | 11.6 (9.4-14.3) | 10.3 (7.5-14.0) |
| Atrial fibrillation | 16.3 (13.7-19.2) | 16.2 (13.8-19.0) | 13.8 (13.0-14.7) | 17.5 (17.2-17.8) | 17.0 (16.3-17.7) | 17.4 (12.9-23.0) | 17.9 (17.2-18.6) | 4.2 (2.4-7.4) | 9.5 (6.2-14.4) | 15.1 (14.5-15.7) | <0.8 | 12.4 (9.3-16.3) |
| Autoimmune condition | 18.6 (15.9-21.7) | 33.9 (30.6-37.3) | 13.7 (12.9-14.6) | 37.4 (37.0-37.8) | 19.9 (19.2-20.6) | 18.8 (14.2-24.5) | 32.6 (31.8-33.4) | 13.8 (10.1-18.5) | 27.5 (21.8-34.1) | 12.0 (11.5-12.5) | 18.5 (15.7-21.7) | 22.4 (18.3-27.1) |
| Bronchiectasis | <1.4 | 2.9 (1.9-4.3) | 1.1 (0.9-1.4) | 1.4 (1.3-1.5) | 1.5 (1.3-1.7) | 5.5 (3.2-9.4) | 0.8 (0.7-1.0) | <1.9 | <2.5 | 4.1 (3.8-4.4) | 1.2 (0.6-2.4) | <1.5 |
| Cancer * | 28.2 (25.0-31.7) | 37.4 (34.1-40.9) | 12.9 (12.1-13.7) | 30.3 (30.0-30.6) | 29.5 (28.7-30.4) | 47.2 (40.7-53.8) | 37.3 (36.5-38.1) | 14.9 (11.1-19.7) | 28.0 (22.2-34.6) | 19.0 (18.4-19.6) | 9.6 (7.6-12.1) | 27.1 (22.7-32.1) |
| Cardiac arrhythmia | 28.5 (25.3-32.0) | 24.4 (21.5-27.6) | 18.9 (18.0-19.9) | 25.6 (25.3-25.9) | 28.0 (27.2-28.8) | 28.0 (22.5-34.3) | 25.6 (24.9-26.4) | 4.6 (2.6-7.9) | 11.0 (7.4-16.1) | 26.4 (25.7-27.1) | 5.7 (4.2-7.8) | 19.1 (15.3-23.6) |
| Cerebrovascular disease | 6.6 (5.0-8.7) | 10.8 (8.8-13.2) | 7.3 (6.7-8.0) | 10.4 (10.2-10.6) | 9.0 (8.5-9.6) | 7.3 (4.5-11.5) | 8.5 (8.0-9.0) | 4.6 (2.6-7.9) | 6.5 (3.8-10.8) | 4.0 (3.7-4.3) | 4.0 (2.7-5.8) | 10.9 (8.0-14.7) |
| Chronic Liver Disease | 3.0 (2.0-4.6) | 3.6 (2.5-5.2) | 2.3 (2.0-2.7) | 2.5 (2.4-2.6) | 3.2 (2.9-3.5) | 9.6 (6.4-14.2) | 7.2 (6.8-7.7) | - | - | 2.2 (2.0-2.4) | <0.8 | 3.5 (2.0-6.0) |
| CKD * | 29.8 (26.5-33.3) | 39.5 (36.1-43.0) | 21.6 (20.6-22.6) | 40.0 (39.6-40.4) | 36.0 (35.1-36.9) | 33.9 (27.9-40.4) | 36.3 (35.5-37.1) | 26.1 (21.1-31.8) | 23.0 (17.7-29.3) | 23.0 (22.4-23.7) | 3.5 (2.3-5.2) | 11.2 (8.3-15.0) |
| Depression | 15.6 (13.1-18.5) | 14.3 (12.0-17.0) | 10.7 (10.0-11.5) | 12.8 (12.6-13.1) | 14.9 (14.2-15.6) | 19.3 (14.6-25.0) | 21.2 (20.5-21.9) | 6.9 (4.4-10.6) | 3.0 (1.4-6.4) | 18.2 (17.6-18.8) | 11.9 (9.6-14.6) | 8.8 (6.2-12.3) |
| Heart disease * | 63.2 (59.5-66.7) | 80.0 (77.0-82.7) | 47.4 (46.2-48.6) | 81.4 (81.1-81.7) | 67.7 (66.8-68.6) | 65.6 (59.1-71.6) | 77.2 (76.5-77.9) | 44.8 (38.9-50.9) | 49.5 (42.6-56.4) | 43.7 (42.9-44.5) | 18.7 (15.9-21.9) | 46.5 (41.3-51.8) |
| Heart failure | 18.2 (15.5-21.2) | 22.6 (19.8-25.7) | 19.9 (19.0-20.9) | 26.8 (26.5-27.1) | 21.2 (20.4-22.0) | 19.7 (15.0-25.5) | 20.4 (19.7-21.1) | 4.6 (2.6-7.9) | 8.5 (5.4-13.2) | 12.3 (11.8-12.8) | 2.0 (1.2-3.4) | 5.3 (3.4-8.2) |
| Hypertension * | 72.4 (69.0-75.6) | 86.9 (84.3-89.1) | 58.8 (57.6-60.0) | 90.0 (89.8-90.2) | 79.1 (78.3-79.8) | 75.2 (69.1-80.5) | 89.1 (88.5-89.6) | 30.7 (25.4-36.5) | 49.5 (42.6-56.4) | 39.0 (38.2-39.8) | 43.1 (39.3-46.9) | 66.8 (61.6-71.6) |
| Interstitial lung disease | 1.6 (0.9-2.8) | 2.5 (1.6-3.9) | 2.1 (1.8-2.5) | 2.6 (2.5-2.7) | 2.4 (2.1-2.7) | 4.1 (2.2-7.6) | 1.6 (1.4-1.8) | <1.9 | - | 0.5 (0.4-0.6) | <0.8 | <1.5 |
| Myocardial infarction | 12.6 (10.3-15.3) | 8.6 (6.8-10.8) | 4.6 (4.1-5.1) | 6.3 (6.1-6.5) | 10.7 (10.1-11.3) | 10.6 (7.2-15.4) | 6.7 (6.3-7.1) | <1.9 | 6.0 (3.5-10.2) | 2.7 (2.5-3.0) | <0.8 | 3.5 (2.0-6.0) |
| Obesity | 47.5 (43.8-51.2) | 57.3 (53.8-60.8) | 20.1 (19.1-21.1) | 35.8 (35.4-36.2) | 60.7 (59.8-61.6) | 49.1 (42.5-55.7) | 55.2 (54.3-56.1) | 50.6 (44.6-56.6) | 33.0 (26.9-39.8) | 52.1 (51.3-52.9) | 14.4 (11.9-17.3) | 25.6 (21.2-30.5) |
| Sleep apnea | 21.5 (18.6-24.7) | 9.6 (7.7-11.9) | 10.9 (10.2-11.7) | 9.8 (9.6-10.0) | 14.4 (13.8-15.1) | 23.4 (18.3-29.4) | 30.6 (29.8-31.4) | <1.9 | <2.5 | 6.0 (5.6-6.4) | 1.2 (0.6-2.4) | 2.1 (1.0-4.2) |
| T2DM * | 34.5 (31.0-38.1) | 50.4 (46.9-53.9) | 35.9 (34.7-37.1) | 57.6 (57.2-58.0) | 40.6 (39.7-41.5) | 40.8 (34.5-47.4) | 54.5 (53.6-55.4) | 24.9 (20.0-30.5) | 34.0 (27.8-40.8) | 21.6 (21.0-22.2) | 18.2 (15.4-21.4) | 20.6 (16.6-25.2) |
*Prevalent conditions measured any time in the past, others within the previous year. Grey =US database. Pink=South Korean database. Yellow=European database. CKD=Chronic kidney disease. T2DM=type 2 diabetes mellitus.