Table 5. Prevalence of treatments in patients with COPD in the 30 days before COVID-19 hospitalization.
| CU-AMC HDC %
(95%CI) |
CUIMC %
(95%CI) |
HealthVerity
% (95%CI) |
IQVIA-
OpenClaims % (95%CI) |
OptumEhr % (95%CI) | VA-OMOP %
(95%CI) |
HIRA % (95%CI) | SIDIAP %
(95%CI) |
|
|---|---|---|---|---|---|---|---|---|
|
Systemic
corticosteroids |
28.4 (23.6-33.8) | 13.4 (10.5-16.9) | 7.5 (6.3-8.9) | 12.7 (12.3-13.1) | 16.1 (15.1-17.2) | 16.1 (15.1-17.2) | 23.4 (17.2-30.9) | 17.9 (16.9-19.0) |
|
Inhaled
corticosteroid |
25.8 (21.2-31.0) | 7.6 (5.5-10.4) | 9.6 (8.3-11.1) | 14.0 (13.6-14.4) | 14.4 (13.4-15.5) | 26.5 (25.2-27.8) | <6.8 | 33.7 (32.4-35.0) |
| SABA | 33.4 (28.3-38.9) | 13.0 (10.2-16.4) | 9.5 (8.2-11.0) | 14.4 (14.0-14.8) | 20.6 (19.4-21.8) | 26.9 (25.6-28.2) | <3.4 | 14.3 (13.3-15.3) |
| SAMA | 17.1 (13.3-21.8) | 6.0 (4.2-8.6) | 4.1 (3.2-5.2) | 4.9 (4.7-5.1) | 11.1 (10.2-12.0) | 10.8 (9.9-11.7) | <3.4 | 22.4 (21.2-23.6) |
| LABA | 19.7 (15.6-24.6) | 5.1 (3.4-7.6) | 7.1 (6.0-8.4) | 10.6 (10.3-10.9) | 10.9 (10.0-11.8) | 18.4 (17.3-19.5) | 4.1 (1.9-8.7) | 30.4 (29.1-31.7) |
| LAMA | 7.4 (4.9-10.9) | 1.3 (0.6-2.8) | 3.8 (3.0-4.8) | 6.4 (6.1-6.7) | 7.2 (6.5-8.0) | 13.8 (12.8-14.8) | <3.4 | 19.3 (18.2-20.4) |
| Mucolytics | <3.3 | <1.1 | 0.8 (0.5-1.4) | 0.2 (0.2-0.3) | 1.3 (1.0-1.7) | 1.5 (1.2-1.9) | 71.0 (63.1-77.8) | 12.4 (11.5-13.4) |
|
Beta-lactam
penicillins |
7.0 (4.6-10.5) | 4.7 (3.1-7.1) | 3.3 (2.5-4.3) | 4.0 (3.8-4.2) | 5.9 (5.2-6.6) | 5.9 (5.3-6.6) | 13.1 (8.6-19.6) | 11.7 (10.8-12.6) |
| Fluoroquinolones | 4.7 (2.8-7.7) | 4.7 (3.1-7.1) | 2.8 (2.1-3.7) | 4.3 (4.1-4.5) | 3.7 (3.2-4.3) | 2.8 (2.4-3.3) | 9.7 (5.9-15.6) | 10.0 (9.2-10.9) |
| Macrolides | 11.4 (8.3-15.5) | 9.4 (7.0-12.5) | 6.1 (5.0-7.4) | 8.9 (8.6-9.2) | 9.1 (8.3-10.0) | 7.5 (6.8-8.3) | 9.7 (5.9-15.6) | 10.6 (9.8-11.5) |
| Acetaminophen | 34.4 (29.2-40.0) | 19.5 (16.1-23.4) | 3.9 (3.1-5.0) | 8.4 (8.1-8.7) | 24.2 (23.0-25.5) | 30.3 (29.0-31.6) | 45.5 (37.6-53.6) | 60.4 (59.0-61.8) |
| NSAIDs | 54.2 (48.5-59.8) | 7.4 (5.3-10.2) | 3.5 (2.7-4.5) | 19.7 (19.3-20.2) | 7.8 (7.0-8.6) | 48.8 (47.4-50.2) | 27.6 (21.0-35.4) | 9.2 (8.4-10.1) |
| Opioids | 28.8 (24.0-34.2) | 8.3 (6.1-11.2) | 5.3 (4.3-6.5) | 9.0 (8.7-9.3) | 13.7 (12.7-14.7) | 12.5 (11.6-13.5) | 48.3 (40.3-56.4) | 17.6 (16.6-18.7) |
| Oxygen | 7.7 (5.2-11.3) | <1.1 | 2.8 (2.1-3.7) | 2.4 (2.2-2.6) | 2.5 (2.1-3.0) | 1.4 (1.1-1.8) | 4.8 (2.3-9.6) | <0.1 |
Grey =US database. Pink=South Korean database. Yellow=European database. SABA=short-acting beta-agonist. SAMA=short-acting muscarinic-antagonist. LABA=long-acting beta-agonist. LAMA=Long-acting muscarinic-antagonist. NSAIDs=non-steroidal anti-inflammatory drugs.