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. 2023 Jan 24;14(3):364–375. doi: 10.1111/jdi.13938

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© 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Sinomenine (SIN) in Sinomenium acutum might alleviate diabetic peripheral neuropathic pain by regulating inositol‐requiring enzyme 1 alpha–X‐box binding protein 1 pathway through prostaglandin‐endoperoxide synthase 2 (PTGS2). (a) Protein–protein interaction network of candidate genes analyzed using String database. (b) Protein–protein interaction network constructed using Cytoscape. (c) Protein–protein interaction network of top 10 core genes screened out using Cytoscape. (d) Top 10 core genes scored using Cytoscape. (e) Bar chart of the expression of PTGS2 in GSE95849 microarray (n = 6 for the control and diabetic peripheral neuropathic pain groups, respectively). DPN, diabetic peripheral neuropathy. mRNA, messenger ribonucleic acid.