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. 2022 Dec 24;18(1):78–88. doi: 10.4103/1735-5362.363598

Table 5.

Association of the mRNA expression level of Notch4 with clinicopathological characteristics of patients.

Variables Expression of Notch4
OR 95% CI P-Value
Low (%) High (%)
Grade     0.640    
    Grade 1 12 (34.3%) 20 (57.1%)   0.245-1.672 0.362
    Grades 2 & 3 25 (67%) 15 (42.9%)      
N stage     12.267 3.769-39.634 0.0001
    N0 & N1 32 (86.5%) 12 (34.3%)      
    N1 & N2 5 (13.5%) 23 (65.7%)      
T Stage     2.236 0.760-6.577 0.144
    T1 & T2 30 (81.1%) 23 (65.7%)      
    T3 & T4 7 (18.9%) 12 (34.3%)      
Extracapsular nodal extension     0.264 0.075-0.932 0.038
    Yes 33 (89.2%) 24 (68.6%)      
    No 14 (37.8%) 11 (31.4%)      
DCIS histology     1.167 0.445-3.058 0.754
    Comedo Type 23 (62.2%) 12 (34.3%)      
    Non Comedo 34 (91.9%) 23 (65.7%)      
Nipple involvement     0796 0.630-1.006 0.056
    No 34 (91.9%) 26 (74.3%)      
    Yes 7 (8.1%) 9 (25.7%)      
Lymphatic invasion     0.922 0.310-2.740 0.884
    No 9 (24.3%) 8 (22.9%)      
    Yes 28 (75.7%) 27 (77.1%)      
Perineural invasion     0.723 0.282-1.851 0.499
    Yes 23(62.2%) 19(54.3%)      
    No 14(37.8%) 16(45.7%)      
PR status     1.038 0.39-2.741 0.940
    Positive 24 (64.9%) 23 (65.7%)      
    Negative 13 (35.1%) 12 (34.3%)      
HER-2 status     1.244 0.436-3.555 0.683
    Positive 9 (24.3%) 10 (28.6%)      
    Negative 28 (75.7%) 25 (71.4%)      
P53 status     1.595 0.588-4.329 0.359
    Positive 10 (27%) 13 (37.1%)      
    Negative 27 (73%) 22 (92.9%)      

OR, Odd ratio; DSCI, ductal carcinoma in situ; PR, progesterone receptor.