Table 1.
Antimicrobial (MIC, μM) activities1 of compounds 7–9 and squalamine (1).
| Compound | S.a. a | E.c. b | K.p. c | P.a. d | A.b. e | C.a. f | C.n. g |
|---|---|---|---|---|---|---|---|
| 7a | 3.4 | >27 | >27 | >27 | >27 | 14 | ≤0.21 |
| 7b | ≤0.21 | >26 | >26 | >26 | >26 | 13 | ≤0.21 |
| 7c | ≤0.21 | >26 | >26 | >26 | >26 | 13 | ≤0.21 |
| 7d | ≤0.20 | >26 | >26 | >26 | >26 | 13 | ≤0.20 |
| 7e | ≤0.20 | >25 | >25 | >25 | >25 | ≤0.20 | 0.80 |
| 7f | ≤0.19 | >25 | >25 | >25 | >25 | ≤0.19 | ≤0.19 |
| 8a | 27 | >27 | >27 | >27 | >27 | 27 | >27 |
| 8b | 1.7 | >26 | >26 | >26 | >26 | 27 | >27 |
| 8c | ≤0.21 | >26 | >26 | >26 | >26 | 13 | 26 |
| 8d | ≤0.20 | >26 | >26 | >26 | >26 | 26 | 13 |
| 8e | ≤0.20 | >25 | >25 | >25 | >25 | 3.2 | 1.6 |
| 8f | ≤0.19 | >25 | >25 | >25 | >25 | 3.1 | ≤0.19 |
| 9a | ≤0.21 | 6.8 | >27 | >27 | 27 | ≤0.21 | ≤0.21 |
| 1 | ≤0.28 | ≤0.28 | ≤0.28 | 18 | ≤0.28 | 4.5 | 0.56 |
All values presented as the mean (n = 2). a Staphylococcus aureus ATCC 43300 (MRSA) with vancomycin (MIC 0.7 μM) used as a positive control; b Escherichia coli ATCC 25922 with colistin (MIC0.1 μM); c Klebsiella pneumoniae ATCC 700603 with colistin (MIC 0.2 μM); d Pseudomonas aeruginosa ATCC 27853 with colistin (MIC 0.2 μM); e Acinetobacter baumannii ATCC 19606 with colistin (MIC0.2 μM); f Candida albicans ATCC 90028 with fluconazole (MIC 0.4 μM) as a positive control; g Cryptococcus neoformans ATCC 208821 with fluconazole (MIC 26 μM) as a positive control.