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. 2023 Jan 30;12(2):320. doi: 10.3390/antiox12020320

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Oxidative damage biomarkers. Although slight increases were observed in the levels of 8OHdG, a biomarker of oxidative DNA damage (A), and 8OHG, a biomarker of oxidative RNA damage (B), with doxorubicin administration relative to saline controls, this was not significant (ns; 1-way ANOVA, Tukey’s multiple comparison test). Supplementation with ET also appeared to decrease oxidative markers of both DNA and RNA, but this was not significant (A,B). No differences were seen in heart protein carbonyls (C) between any of the groups. A similar trend in plasma protein carbonyls (D) was seen as with nucleic acid oxidation markers in heart, but again this was not significantly different.

Oxidative damage biomarkers. Although slight increases were observed in the levels of 8OHdG, a biomarker of oxidative DNA damage (A), and 8OHG, a biomarker of oxidative RNA damage (B), with doxorubicin administration relative to saline controls, this was not significant (ns; 1-way ANOVA, Tukey’s multiple comparison test). Supplementation with ET also appeared to decrease oxidative markers of both DNA and RNA, but this was not significant (A,B). No differences were seen in heart protein carbonyls (C) between any of the groups. A similar trend in plasma protein carbonyls (D) was seen as with nucleic acid oxidation markers in heart, but again this was not significantly different.