Table 2.
Inhibition activity of meleagrin and its chemically prepared derivatives. This table was prepared based on information from Zheng et al., (2013) [59].
| FabI inhibitors | Chemical structure | MIC (μg/mL) | IC50 (μM) | |
|---|---|---|---|---|
| S. aureus RN4220 | E. coli KCTC 1924 | [14C] acetate incorporation | ||
| Meleagrin |
|
64 | 32 | 64 |
| Compound 2 |
|
64 | 64 | 64 |
| Compound 3 |
|
64 | 32 | 64 |
| Compound 4 |
|
64 | 32 | 64 |
| Compound 5 |
|
16 | 8 | 16 |
| Compound 6 |
|
16 | 8 | 16 |
| Compound 7 |
|
>128 | >128 | >128 |