. 2023 Feb 1;12(2):344. doi: 10.3390/antiox12020344

Table 1.

Stability, H₂S release, and vasodilating activity of H₂S donors.

Compd ¹	Stability and H₂S Release In Human Serum				Vasodilating Activity
Compd ¹	% Compd (at 1, 4, 24 h) ± SE or Half-Life		% H₂S mol/mol (at 1, 4, 24 h) Hours ± SE		EC₅₀ (μM) ± SEM [% Vasodilation]	+ Glib. 10 μM EC₅₀ (μM) ± SEM [% Vasodilation]
1	88 ± 1	1 h	0.4 ± 0.1	1 h	NA	NA
	35 ± 1	4 h	1.5 ± 0.1	4 h
	8.0 ± 0.5	24 h	3.9 ± 0.9	24 h
2	t_1/2 < 30 min		0.6 ± 0.3	1 h	NA	NA
			1.8 ± 0.3	4 h
			5 ± 1	24 h
3	80.0 ± 1.0	1 h	1.5 ± 0.2	1 h	NA	NA
	62 ± 2	4 h	8.2 ± 0.3	4 h
	44 ± 1	24 h	23 ± 2	24 h
4	t_1/2 < 30 min		5.8 ± 0.2	1 h	64 ± 6	[44 ± 3] ²
			10 ± 1	4 h
			24.2 ± 0.9	24 h
5	64 ± 1	1 h	2.7 ± 0.2	1 h	[16 ± 4] ³
	39 ± 1	4 h	11 ± 2	4 h
	16 ± 1	24 h	21 ± 1	24 h
6	t_1/2 < 30 min		5.8 ± 0.2	1 h	47 ± 8	[34 ± 7] ²
			10 ± 1	4 h
			24.2 ± 0.8	24 h
7	19.8 ± 0.7	1 h	0.3 ± 0.2	1 h	[12 ± 1] ³
	0	4 h	1.4 ± 0.2	4 h
	0	24 h	5 ± 1	24 h
8	t_1/2 < 30 min		16 ± 1	1 h	40 ± 3	40 ± 4
			25.8 ± 0.4	4 h
			47 ± 1	24 h
9	94.2 ± 0.2	1 h	0.4 ± 0.1	1 h	78 ± 7	262 ± 62
	90.0 ± 0.8	4 h	1.7 ± 0.6	4 h
	83 ± 1	24 h	4.4 ± 0.9	24 h
10	t_1/2 = 2.4 h		1.8 ± 0.3	1 h	[29 ± 3] ⁴
			7.5 ± 0.6	4 h
			12.0 ± 0.9	24 h
11	96.3 ± 0.2	1 h	0.4 ± 0.4	1 h	[42 ± 3] ²
	90.0 ± 0.9	4 h	4 ± 1	4 h
	53 ± 2	24 h	33 ± 4	24 h
12	t_1/2 = 2.7 h		17 ± 8	1 h	20 ± 2	20 ± 3
			63 ± 30	4 h
			146 ± 34	24 h
13	99.2 ± 0.1	1 h	0	1 h	[39 ± 8] ²
	96.0 ± 0.8	4 h	0.7 ± 0.2	4 h
	94.3 ± 2	24 h	2.4 ± 0.5	24 h
14	t_1/2 = 30 min		0	1 h	[37 ± 3] ⁴
			0.5 ± 0.3	4 h
			1.8 ± 0.6	24 h
15	99.2 ± 0.1	1 h	0.2 ± 0.4	1 h	[17 ± 3] ³
	95 ± 1	4 h	1.3 ± 0.2	4 h
	94.8 ± 2	24 h	2.8 ± 0.5	24 h
16	t_1/2 = 1.5 h		0.4 ± 0.2	1 h	[25 ± 5] ²
			1.7 ± 0.5	4 h
			2.5 ± 0.9	24 h
17	91.6 ± 0.3	1 h	0.2 ± 0.2	1 h	[27 ± 6] ³
	85.0 ± 0.1	4 h	1.0 ± 0.3	4 h
	64.7 ± 0.2	24 h	6 ± 1	24 h
18	t_1/2 = 3.7 h		1.4 ± 0.4	1 h	[33 ± 6] ⁴
			11.0 ± 0.3	4 h
			44 ± 2	24 h

¹ Compound. ² Percent vasodilation at the maximum concentration testable (100 μM). ³ Percent vasodilation at the maximum concentration testable (300 μM). ⁴ Percent vasodilation at the maximum concentration testable (10 μM).