Table 2.

Version 2 of the Cochrane risk-of-bias tool for randomized trials to assess the risk of bias in the findings of each study. The tool is structured into five domains. Trials are judged for each domain as either having a ‘Low’/’Some concerns’/’High’ risk of bias with an overall judgement of the risk.

Author	1. Risk of Bias Arising from the Randomization Process	2.1 Risk of Bias Due to Deviations from the Intended Interventions (Effect of Assignment to Intervention)	2.2 Risk of Bias Due to Deviations from the Intended Interventions (Effect of Adhering to Intervention)	3. Risk of Bias Due to Missing Outcome Data	4. Risk of Bias in the Measurement of the Outcome	5. Risk of Bias in the Selection of the Reported Result	Overall Risk-of-Bias Judgement
Hojer et al. [9]	Low	Low	Low	Some concerns	Low	High	High
Matheson et al. [10]	Low	Low	Low	Some concerns	Low	High	High
Bartlett et al. [11]	Low	Low	Low	Some concerns	Low	Some concerns	Some concerns
Ishida et al. [12]	High	Low	High	Low	Low	High	High
Sato et al. [13]	Some concerns	Low	High	Low	Low	High	High
Sadahiro et al. [14]	Low	Low	Low	Some concerns	Low	High	High
Hjalmarsson et al. [15]	High	Low	High	Low	Low	High	High
Anjum et al. [16]	Low	Low	Low	Some concerns	Low	Low	Some concerns
Abis et al. [17]	High	Low	Some concerns	Low	Low	High	High
Koskenvuo et al. [18]	High	Low	High	Low	Low	High	High
Mulder et al. [19]	Low	Low	Low	Some concerns	Low	Some concerns	Some concerns
Papp et al. [20]	High	Some concerns	High	Low	Low	High	High
Futier et al. [21]	Low	Low	Low	Some concerns	Low	Some concerns	Some concerns