Table 3.
Characterization of included RCTs.
| Author | Year of Publication |
Study Design | Number of Patients |
Endpoints | Antibiotic Group | Control Group | Statistical Significance |
|---|---|---|---|---|---|---|---|
| Höjer et al. [9] | 1977 | Single-center, prospective, double-blinded, randomized trial | 118 | 58 | 60 | ||
| Anastomotic Leak | 2 | 5 | p < 0.001 | ||||
| SSI | 5 | 25 | p < 0.001 | ||||
| Matheson et al. [10] | 1978 | Single-center, double-blinded, randomized controlled trial | 110 | 51 | 59 | ||
| Anastomotic Leak | 0 | 7 | p < 0.02 | ||||
| SSI | 9 | 25 | p < 0.01 | ||||
| Bartlett et al. [11] | 1978 | Multicenter, double-blinded, randomized trial | 116 | 56 | 60 | ||
| Anastomotic Leak | 2 | 10 | p = 0.05 | ||||
| SSI | 5 | 21 | p = 0.002 | ||||
| Ishida et al. [12] | 2001 | Single-center, single-blinded, randomized controlled trial | 143 | 72 | 71 | ||
| Anastomotic Leak | 1 | 2 | p = 0.050 | ||||
| SSI | 8 | 17 | p = 0.035 | ||||
| Sato et al. [13] | 2009 | Multicenter, randomized trial | 100 | 49 | 51 | ||
| Anastomotic Leak | 7 | 5 | p = 0.8293 | ||||
| SSI | 20 | 23 | p = 0.8293 | ||||
| Sadahiro et al. [14] | 2014 | Single-center, double-blinded, randomized trial | 194 | 99 | 95 | ||
| Anastomotic Leak | 1 | 7 | p = 0.014 | ||||
| SSI | 18 | 17 | p = 0.004 | ||||
| Hjalmarsson et al. [15] | 2015 | Prospective, multicenter, single-blinded, randomized controlled trial | 985 | 486 | 499 | ||
| Anastomotic Leak | 17 | 17 | p = 0.95 | ||||
| SSI | 34 | 18 | p = 0.022 | ||||
| Anjum et al. [16] | 2017 | Single-center, double-blinded, prospective, randomized trial | 184 | 91 | 93 | ||
| Anastomotic Leak | 0 | 4 | p = 0.004 | ||||
| SSI | 8 | 26 | p = 0.001 | ||||
| Abis et al. [17] | 2018 | Superiority, open-label, multicenter, randomized trial | 455 | 228 | 227 | ||
| Anastomotic Leak | 14 | 22 | OR 0.61 (0.30–1.22) | ||||
| SSI | 5 | 24 | OR 0.19 (0.07–0.51) | ||||
| Koskenvuo et al. [18] | 2019 | Multicenter, parallel, single-blinded randomized trial | 396 | 196 | 200 | ||
| Anastomotic Leak | 7 | 8 | CI 1.13 (0.40–3.16) | ||||
| SSI | 13 | 21 | CI 1.65 (0.80–3.40) | ||||
| Mulder et al. [19] | 2020 | Multicenter, double-blind, placebo-controlled randomized trial | 78 | 39 | 39 | ||
| Anastomotic Leak | 1 | 2 | RR 0.50 (0.05–5.29) | ||||
| SSI | 4 | 5 | RR 0.80 (0.23–2.78) | ||||
| Papp et al. [20] | 2021 | Multicentre, prospective, randomized, assessor-blinded trial |
529 | 253 | 276 | ||
| Anastomotic Leak | 4 | 13 | p = 0.020 | ||||
| SSI | 8 | 27 | p = 0.001 | ||||
| Futier et al. [21] | 2022 | Multicenter, double-blinded, randomized, placebo-controlled trial | 926 | 463 | 463 | ||
| Anastomotic Leak | 22 | 37 | p = 0.046 | ||||
| SSI | 60 | 100 | p = 0.001 |