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UA in vitro skin permeation study; values are presented as means ± Dev. st of three replicates. Data were analyzed with two-way ANOVA followed by Tukey’s posthoc test; * p < 0.01 4-h vs. 1-h, # p < 0.01 2-h vs. 1-h, $ p < 0.01 4-h vs. 2-h in the same group.
