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. 2023 Feb 9;12(2):429. doi: 10.3390/antiox12020429

Figure 1.

Figure 1

NOX2 activation and regulation. (1) When activated, PKC phosphorylates Ser304, Ser315, Ser320, and Ser328 of p47phox; (2) the phosphorylation of p47phox uncovers its N-terminal SH3 domain that then binds the proline-rich region (PRR) in p22phox. The PX domain of p47phox binds the products of PI3K; (3) the activation of GTPase Rac2 mediates the translocation of p67phox, which associates with p47phox to the cytochrome; (4) Rac2 directly binds to the flavocytochrome favoring the initial steps of the electron transfer reaction.